Lab Technician at the epigenetic face of cancer metabolism Lab

Updated: 3 months ago
Job Type: PartTime
Deadline: 15 Mar 2021

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In November 2013, the Centre for Genomic Regulation (CRG) received the 'HR Excellence in Research ' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

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The role

We are looking for a Lab Technician that will be responsible for performing the validation of a CRISPR-Cas9 knock out screen that we recently performed. The candidate will work together with a postdoctoral fellow for the first 2 months. During the 2 months, the candidate will be trained to perform the required experiments. After that time, the candidate is expected to actively communicate with her and the group leader to decide the experiments to be performed for the best development of the project.

About the lab

We are a team of researchers crazy about science, and funded by the European Council (ERC starting Grant 2019, EPICAMENTE). We investigate the connection between metabolism and epigenetics, and its role in cancer development and progression.

The central role of metabolic rewiring during cancer progression is undeniable, but its direct impact on chromatin functions has been poorly investigated.

The team recently described that enzymes of central metabolism can localize on chromatin in cancer cells. However, their chromatin-associated roles remain mostly elusive. Therefore, the scope of our research is to dissect the role of enzymatic activities on chromatin, with a particular focus on cancer. To do so, we apply chemical biology and functional genomics approaches to unbiased chromatin reporters (REDS) for selected metabolic enzymes. We aim to identify the molecular networks defining the direct interplay between chromatin and cancer metabolism. Our research focuses on a brand-new area of cancer biology and has the potential to uncover novel chromatin-associated metabolic vulnerabilities. The breakthrough aspect of our investigation has been recognized by the European Research Council which, in 2019, awarded us with one of the prestigious ERC starting grant ( ).

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